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Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period.
Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses.
Once integrated, the virus may become latent, allowing the virus and its host cell to avoid detection by the immune system.
Alternatively, the virus may be transcribed, producing new RNA genomes and viral proteins that are packaged and released from the cell as new virus particles that begin the replication cycle anew.
This is a concern in places where diverse subtypes are prevalent.