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Angels require a particular vessel to reach their full potential, people being "chosen" to be their hosts or "true vessels".
Most angels are portrayed as emotionless authoritarian beings.
The show features two main characters, Jared Padalecki as Sam Winchester and Jensen Ackles as Dean Winchester, brothers who travel across the country in a black 1967 Chevrolet Impala to hunt demons, supernatural creatures, and other paranormal entities, many of them based on folklore, myths, and American urban legends.
In addition, Supernatural chronicles the relationship between the brothers and their father, John Winchester, as they seek to avenge and understand the murder of their mother at the hands of the demon Azazel.
Sam asks him if there is any way to keep a soul out of its body.