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The mean concentration values of ICAM-1 in the affected subjects was lower than in unaffected relatives and controls.

In general, serum ICAM-1 levels are increased in chronic inflammatory conditions, in contrast to the affected subjects in the present family.

Intercellular adhesion molecule-1 (ICAM-1 or CD54) is a glycoprotein membrane and a member of the immunoglobulin superfamily which plays a central role in cell to cell mediated immune response and is a ligand for leucocyte function associated antigen-1 (LFA-1).

Genetic studies using different types of back cross mice, either protected or not against vaginal candidiasis, after peripheral immunisation, showed that candidate loci for the immune response to vaginal candidiasis included ICAM-1, the ICAM-1 related sequence 1, and the Fc epsilon RII.

In CMCs both autosomal dominant and recessive inheritance models have been reported.


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